Bisphosphonates: Mode of Action and Pharmacology
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چکیده
منابع مشابه
Bisphosphonates: Mode of Action and Pharmacology
The profound effects of the bisphosphonates on calcium metabolism were discovered over 30 years ago, and they are now well established as the major drugs used for the treatment of bone diseases associated with excessive resorption. Their principal uses are for Paget disease of bone, myeloma, bone metastases, and osteoporosis in adults, but there has been increasing and successful application in...
متن کاملBisphosphonates: mode of action and pharmacology.
The profound effects of the bisphosphonates on calcium metabolism were discovered over 30 years ago, and they are now well established as the major drugs used for the treatment of bone diseases associated with excessive resorption. Their principal uses are for Paget disease of bone, myeloma, bone metastases, and osteoporosis in adults, but there has been increasing and successful application in...
متن کاملPharmacology aND moDe of actIoN
INtroDuctIoN Of the 25.8 million Americans with type-2 diabetes mellitus, 7 million of these individuals are unaware that they have the disease. Medical costs are 2.3 times higher in patients with diabetes, with health care expenditures exceeding $174 billion annually.1 Complications include kidney failure, nontraumatic lower-extremity amputation, blindness, heart disease, and stroke. Type-2 di...
متن کاملBisphosphonates: mechanisms of action.
T bisphosphonates have been known to chemists since the middle of the 19th century, when the first synthesis occurred in 1865 in Germany (1). Etidronate, the first bisphosphonate to be used to treat a human disease (2), was synthesized exactly 100 yr ago (3). Bisphosphonates were used in industry, mainly as corrosion inhibitors or as complexing agents in the textile, fertilizer, and oil industr...
متن کاملClinical Pharmacology General Pharmacology and Mechanism of Action
Cyanocobalamin occurs as dark red crystals or orthorhombic needles or crystalline red powder. It is very hygroscopic in the anhydrous form, and sparingly to moderately soluble in water (1:80). Its pharmacologic activity is destroyed by heavy metals (iron) and strong oxidizing or reducing agents (vitamin C), but not by autoclaving for short periods of time (15-20 minutes) at 121°C. The vitamin B...
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ژورنال
عنوان ژورنال: Pediatrics
سال: 2007
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.2006-2023h